Company Ticker 202020192018201720162015201420132012201120102009200820072006200520042003200220012000
Virios Therapeutics, LLC VIRI 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AbCellera Biologics Inc. ABCL 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Olema Pharmaceuticals, Inc. OLMA 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Atea Pharmaceuticals, Inc. AVIR 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Galecto, Inc. GLTO 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Foghorn Therapeutics Inc. FHTX 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Orphazyme A/S ORPH 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Nkarta, Inc. NKTX 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zomedica Pharmaceuticals Corp ZOM -27%-73%-38%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Synthetic Biologics Inc SYN -28%-9%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Rexahn Pharmaceuticals Inc RNN 0%0%-54%42%-61%-48%37%65%-18%-66%65%-24%0%0%0%0%0%0%0%0%0%
Palatin Technologies Inc PTN -0%10%-17%69%-23%-10%0%22%50%-70%-64%311%-55%-90%-37%23%6%26%-53%24%35%
Oragenics Inc OGEN -20%-39%-63%-56%-64%69%-68%6%0%0%0%0%0%0%0%0%0%0%0%0%0%
NovaBay Pharmaceuticals Inc NBY 14%-19%-80%17%63%-87%-49%9%-16%-19%-19%102%-73%0%0%0%0%0%0%0%0%
Matinas Biopharma Holdings Inc MTNB -32%260%-48%-17%65%89%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
iBio Inc IBIO 324%-66%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
CorMedix Inc CRMD 4%446%158%-67%-25%6%54%72%157%-85%0%0%0%0%0%0%0%0%0%0%0%
China Pharma Holdings Inc CPHI 102%-12%44%-31%63%-47%-14%75%-70%-78%-21%238%-63%34%0%0%0%0%0%0%0%
Can Fite Biopharma Ltd CANF -44%155%-15%-38%-18%-17%-42%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
BioPharmX Corporation BPMX 0%232%0%-70%-76%-49%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ampio Pharmaceuticals Inc AMPE 208%32%-90%352%-74%2%-52%99%-16%78%0%0%0%0%0%0%0%0%0%0%0%
Actinium Pharmaceuticals Inc ATNM 3589%-44%-41%-25%-73%-45%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zoetis Inc ZTS 24%55%19%36%13%12%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Teva Pharmaceutical Industries Limited TEVA -2%-36%-19%-46%-43%17%47%11%-5%-21%-6%34%-7%51%-27%45%111%48%26%-16%105%
Taro Pharmaceutical Industries Ltd TARO -19%5%-7%-1%-32%4%50%104%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sanofi SNY -4%16%6%10%-1%-3%-12%17%36%19%-14%29%-26%1%7%11%8%26%0%0%0%
Prestige Consumer Healthcare Inc PBH -14%34%-30%-15%1%48%-3%79%78%-6%52%-25%41%-43%4%0%0%0%0%0%0%
Pfizer Inc PFE -5%-11%25%16%4%7%5%26%20%29%0%9%-17%-8%15%-11%-22%18%-22%-13%43%
Perrigo Company PRGO -14%34%-55%6%-42%-13%9%48%7%54%60%24%-7%104%17%-13%11%30%3%43%3%
Novo Nordisk A S NVO 22%26%-12%54%-37%0%0%15%44%4%79%27%-20%58%51%5%35%44%-27%14%39%
Novartis AG NVS -2%11%6%19%-12%-5%19%32%16%1%12%14%-5%-4%11%6%12%27%2%-17%0%
Merck & Company Inc MRK -11%19%40%-1%15%-4%17%27%13%10%3%27%-45%37%43%4%-28%-11%-1%-36%42%
Mallinckrodt plc MNK -94%-78%-30%-55%-33%-25%89%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Lannett Co Inc LCI -25%71%-79%5%-45%-6%30%567%12%-21%-5%18%62%-51%-15%-25%-41%54%0%0%-35%
Johnson & Johnson JNJ 6%13%-5%24%15%1%17%35%11%10%-1%11%-8%4%12%-3%25%-2%-8%14%14%
GlaxoSmithKline PLC GSK -21%23%14%-3%2%-0%-16%29%1%23%-2%19%-22%-1%8%10%6%29%-23%-10%4%
Emergent Biosolutions Inc EBS 66%-8%28%42%-18%47%18%43%-5%-28%73%-48%416%-55%0%0%0%0%0%0%0%
Eli Lilly and Company LLY 27%13%40%18%-10%25%40%7%24%25%4%-6%-21%6%-5%3%-18%13%-18%-14%42%
Dr Reddy& 39 s Laboratories Ltd RDY 72%8%1%-16%-2%-8%24%24%14%-18%54%149%-46%0%69%10%-37%65%2%0%0%
Cambrex Corporation CBM 0%0%-21%-11%15%118%21%57%58%39%-7%21%-45%255%22%-30%8%-16%-30%-4%32%
Bristol Myers Squibb Company BMY -4%24%-13%8%-13%19%14%70%-4%39%9%15%-6%5%20%-6%-7%29%-52%-26%17%
Bausch Health Companies Inc BHC -33%60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Astrazeneca PLC AZN -1%32%14%33%-16%1%24%33%9%6%4%22%0%-17%13%37%-23%41%-23%-8%29%
Allergan plc AGN 0%43%-17%-21%-33%47%92%21%5%28%9%57%-37%8%11%34%6%34%-21%-22%95%
AbbVie Inc ABBV 17%-2%-1%60%10%-7%28%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Abbott Laboratories ABT 25%20%29%52%-12%2%20%-41%20%22%-8%5%-2%18%27%-13%10%19%-27%17%36%
Zogenix Inc ZGNX -62%41%-9%230%-18%34%-60%159%-40%-61%0%0%0%0%0%0%0%0%0%0%0%
ZIOPHARM Oncology Inc ZIOP -48%165%-55%-23%-36%64%17%4%-6%-5%57%410%-84%-41%0%0%0%0%0%0%0%
Zealand Pharma A S ZEAL 5%210%-15%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
XTL Biopharmaceuticals Ltd XTLB 138%-25%-24%-28%-55%-29%-32%0%0%0%0%100%-98%4%-65%0%0%0%0%0%0%
XOMA Corporation XOMA 57%120%-64%744%-84%-63%-47%180%109%-78%-51%13%-82%54%38%-38%-61%56%-57%147650%-100%
Xenetic Biosciences Inc XBIO 45%-14%-15%-55%-74%104%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Xencor Inc XNCR 30%-5%65%-17%80%-9%75%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
VIVUS Inc VVUS 0%15%-56%-56%13%-65%-68%-32%38%4%2%73%3%43%22%-33%17%2%-23%125%-32%
VistaGen Therapeutics Inc VTGN 104%-51%35%-70%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Viking Therapeutics Inc VKTXW -33%8%141%462%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Veru Inc VERU 176%126%23%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Vertex Pharmaceuticals Incorporated VRTX 8%32%11%103%-41%6%60%77%26%-5%-18%41%31%-38%35%162%2%-35%-36%-66%309%
Verona Pharma plc VRNA 13%-37%-19%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Verastem Inc VSTM 57%-59%9%174%-40%-80%-20%30%0%0%0%0%0%0%0%0%0%0%0%0%0%
Vanda Pharmaceuticals Inc VNDA -22%-36%72%-5%71%-35%15%235%-22%-50%-16%2150%-93%-72%0%0%0%0%0%0%0%
United Therapeutics Corporation UTHR 71%-20%-26%3%-8%21%15%112%13%-25%20%68%-36%80%-21%53%97%37%60%-29%-68%
Tyme Technologies Inc TYME 1%-71%-42%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Trillium Therapeutics Inc TRIL 1344%-49%-76%28%-55%40%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Tonix Pharmaceuticals Holding Corp TNXP -40%-50%-94%-27%-94%31%466%-6%0%0%0%0%0%0%0%0%0%0%0%0%0%
Tiziana Life Sciences plc TLSA -24%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Theravance Biopharma Inc TBPH -30%-1%-8%-13%95%10%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Therapix Biosciences Ltd TRPX 225%-64%-39%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
TherapeuticsMD Inc TXMD -49%-39%-37%5%-44%133%-15%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
The Medicines Company MDCO 0%343%-30%-19%-9%35%-28%61%29%32%69%-43%-23%-40%82%-39%-2%84%38%-43%0%
TG Therapeutics Inc TGTX 389%158%-50%76%-61%-25%306%7%0%0%0%0%0%0%0%0%0%0%0%0%0%
Tetraphase Pharmaceuticals Inc TTPH 0%136%-82%56%-60%-75%194%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
TESARO Inc TSRO 0%0%-10%-38%157%41%32%67%0%0%0%0%0%0%0%0%0%0%0%0%0%
Teligent Inc TLGT 52%-66%-62%-45%-26%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Taiwan Liposome Company Ltd TLC -17%-2%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Synthorx Inc THOR 0%305%0%0%0%0%-11%-2%12%19%5%-17%79%3%-15%99%-19%69%-55%55%13%
Synergy Pharmaceuticals Inc SGYP 0%0%-95%-63%7%86%-46%7%0%0%-38%0%0%0%0%0%0%0%0%0%0%
Supernus Pharmaceuticals Inc SUPN 6%-29%-17%58%88%62%10%5%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sunesis Pharmaceuticals Inc SNSS 444%-19%-89%2%-33%-65%-46%13%259%-63%-51%234%-84%-56%-9%0%0%0%0%0%0%
Stemline Therapeutics Inc STML 0%9%-39%46%70%-63%-13%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Stellar Biotechnologies Inc SBOT 0%0%-84%-60%-69%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Spectrum Pharmaceuticals Inc SPPI -11%-56%-54%328%-27%-13%-22%-21%-22%113%55%198%-45%-51%31%-37%-20%364%-51%-11%-69%
Sophiris Bio Inc SPHS -97%-57%-63%-19%57%230%-85%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sonoma Pharmaceuticals Inc SNOA 73%501%-87%8%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Soligenix Inc SNGX -13%69%-61%-1%-80%15%-46%200%8%-85%-24%0%0%0%0%0%0%0%0%0%0%
Sinovac Biotech Ltd SVA 0%-7%-12%34%3%9%-15%95%43%-51%-29%359%-73%120%-42%12%103%0%0%0%0%
SIGA Technologies Inc SIGA 52%-40%63%68%0%0%-56%25%4%-82%141%77%6%-18%295%-43%-28%60%-51%-8%94%
Sierra Oncology Inc SRRA 4666%-75%-65%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sesen Bio Inc SESN 23%-29%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
SELLAS Life Sciences Group Inc SLS 37%246%0%0%0%0%0%0%0%0%39%49%-60%0%0%0%0%0%0%0%0%
Savara Inc SVRA -65%-53%-49%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sarepta Therapeutics Inc SRPT 33%18%96%103%-29%167%-29%-21%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sanofi GCVRZ 0%79%26%0%245%-86%132%-80%42%0%0%0%0%0%0%0%0%0%0%0%0%
Rocket Pharmaceuticals Inc RCKT 140%57%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Rigel Pharmaceuticals Inc RIGL 78%-11%-41%63%-21%33%-20%-56%-18%5%-21%19%-68%114%42%-66%27%1645%-76%-54%0%
Reliv& 39 International Inc RELV -7%-11%-11%3%14%-50%-58%119%9%-35%-40%-26%-44%-5%-33%48%76%37%345%0%21%
Regulus Therapeutics Inc RGLS 59%-16%-93%-54%-74%-46%117%17%0%0%0%0%0%0%0%0%0%0%0%0%0%
Regeneron Pharmaceuticals Inc REGN 30%-0%-1%2%-32%32%49%61%209%69%36%32%-24%20%26%73%-37%-21%-34%-20%176%
Redhill Biopharma Ltd RDHL 49%8%8%-51%-19%-3%13%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Realm Therapeutics plc RLM 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Puma Biotechnology Inc PBYI 17%-58%-79%222%-61%-59%83%452%0%0%0%0%0%0%0%0%0%0%0%0%0%
Pulmatrix Inc PULM 38%260%-83%139%-86%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
PTC Therapeutics Inc PTCT 34%38%106%53%-66%-37%205%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Prothena Corporation plc PRTA -23%55%-73%-24%-28%228%-22%262%0%0%0%0%0%0%0%0%0%0%0%0%0%
ProPhase Labs Inc PRPH 432%-30%83%8%33%3%-9%28%9%-4%0%0%0%0%0%0%0%0%0%0%0%
Progenics Pharmaceuticals Inc PGNX 0%23%-29%-31%41%-19%42%79%-65%56%23%-57%-43%-30%3%46%-9%183%-64%7%-65%
Prana Biotechnology Ltd PRAN 0%0%-59%91%-62%-56%-77%219%50%18%-5%-31%-53%32%95%-62%-18%-37%0%0%0%
Portola Pharmaceuticals Inc PTLA 0%26%-60%117%-56%82%10%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
PLx Pharma Inc PLXP 26%198%-78%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Phio Pharmaceuticals Corp PHIOW 794%80%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Phio Pharmaceuticals Corp PHIO 1558%-52%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Paratek Pharmaceuticals Inc PRTK 37%-13%-71%16%-19%-51%0%0%0%0%9%-8%25%12%2%31%196%8%0%0%0%
Pain Therapeutics Inc PTIE 0%0%-79%0%-67%-14%-58%79%-7%-44%65%-9%-44%19%32%-6%4%191%-74%-38%0%
Pacira Pharmaceuticals Inc PCRX 36%1%-6%41%-58%-13%54%229%102%0%0%0%0%0%0%0%0%0%0%0%0%
Orgenesis Inc ORGS 22%-18%-19%55%-3%-45%-9%16%0%0%0%0%0%0%0%0%0%0%0%0%0%
Organogenesis Holdings Inc ORGO 49%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Oramed Pharmaceuticals Inc ORMP -15%76%-67%47%-28%88%-70%290%18%-7%-33%15%50%-69%0%0%0%0%0%0%0%
Opko Health Inc OPK 163%-50%-39%-47%-7%1%18%75%-2%34%101%13%-43%235%107%21%-62%157%-89%-55%-2%
OncoSec Medical Incorporated ONCS 246%201%-61%33%-48%-75%-2%118%-12%0%0%0%0%0%0%0%0%0%0%0%0%
Onconova Therapeutics Inc ONTX -15%-76%-91%-34%-76%-71%-71%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
OncoMed Pharmaceuticals Inc OMED 0%0%-82%-47%-66%4%-26%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Oncolytics Biotech Inc ONCY -34%97%0%0%0%0%-66%-60%1%-42%157%116%-30%-18%-55%2%33%194%-72%0%0%
Omeros Corporation OMER -4%33%-43%96%-37%-37%119%118%31%-52%17%0%0%0%0%0%0%0%0%0%0%
Ohr Pharmaceutical Inc OHRP 0%0%-95%24%-76%-26%6%47%175%160%-52%0%0%0%0%0%0%0%0%0%0%
Novus Therapeutics Inc NVUS 2402%-62%-61%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Novelion Therapeutics Inc NVLN 0%0%-73%-63%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
NewLink Genetics Corporation NLNK 0%59%-81%-21%-72%-8%81%76%78%0%0%0%0%0%0%0%0%0%0%0%0%
Neurotrope Inc NTRP 0%-74%-49%-6%-61%-40%-47%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Neptune Wellness Solutions Inc NEPT -41%2%8%143%-9%-44%-34%44%-31%18%20%268%-88%0%0%0%0%0%0%0%0%
Nektar Therapeutics NKTR -12%-37%-45%387%-27%9%37%53%32%-56%38%68%-17%-56%-8%-19%49%68%-56%-63%137%
Nature& 39 s Sunshine Products Inc NATR 74%4%-29%-22%54%-29%-3%32%-6%73%5%0%0%0%0%0%0%0%0%0%0%
MYOS RENS Technology Inc MYOS 0%-8%4%15%-37%-73%-8%-32%0%0%0%0%0%0%0%0%0%0%0%0%0%
Mylan N V MYL -5%-28%-35%11%-29%-4%30%58%28%2%15%86%-30%-29%1%14%-30%64%-6%50%1%
Mustang Bio Inc MBIO 1%28%-75%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Molecular Templates Inc MTEM -33%248%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Mirati Therapeutics Inc MRTX 74%200%132%284%-85%71%11%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Millendo Therapeutics Inc MLND -69%-16%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Midatech Pharma PLC MTP 199%316%-81%-70%-43%0%0%0%0%2%17%83%-31%0%0%0%0%0%0%0%0%
Merrimack Pharmaceuticals Inc MACK 105%-16%-62%-63%-48%-30%112%-12%0%0%0%0%0%0%0%0%0%0%0%0%0%
Melinta Therapeutics Inc MLNT 0%-34%-95%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
MEI Pharma Inc MEIP 28%-22%26%46%-10%-63%-47%14%0%0%0%0%0%0%0%0%0%0%0%0%0%
MediciNova Inc MNOV -22%-20%26%7%70%17%42%30%-4%-64%-33%343%-65%-65%0%0%0%0%0%0%0%
Marker Therapeutics Inc MRKR -49%-48%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
MannKind Corporation MNKD 148%25%-54%-27%-56%-72%0%125%-8%-69%-8%155%-57%-52%46%-29%0%0%0%0%0%
Madrigal Pharmaceuticals Inc MDGL 27%-20%23%516%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
MacroGenics Inc MGNX 113%-16%-33%-7%-34%-12%28%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Lipocine Inc LPCN 279%-73%-62%-7%-72%146%-36%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ligand Pharmaceuticals Incorporated LGND -6%-22%-1%35%-6%104%1%154%75%33%-31%-21%-43%-41%-2%0%0%0%0%0%0%
Lifevantage Corporation LFVN -40%18%177%-42%-14%5%-21%-25%53%267%56%25%0%0%0%0%0%0%0%0%0%
Lexicon Pharmaceuticals Inc LXRX -22%-37%-33%-29%4%109%-49%-19%71%-10%-15%21%-54%-16%-1%-53%32%25%-59%-31%0%
LEAP THERAPEUTICS INC LPTX 89%-44%-68%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kitov Pharma Ltd KTOVW 0%-81%-65%-55%163%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kindred Biosciences Inc KIN -48%-23%16%122%25%-54%-33%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Karyopharm Therapeutics Inc KPTI -21%102%-2%2%-29%-65%63%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kamada Ltd KMDA -4%35%5%-13%31%9%-74%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
KalVista Pharmaceuticals Inc KALV -3%-18%103%38%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Jazz Pharmaceuticals plc JAZZ 7%21%-8%23%-22%-14%29%138%38%96%150%308%-87%0%0%0%0%0%0%0%0%
Ironwood Pharmaceuticals Inc IRWD -16%31%-31%-2%32%-24%32%5%-7%16%0%0%0%0%0%0%0%0%0%0%0%
Ionis Pharmaceuticals Inc IONS -5%12%7%5%-23%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Intra Cellular Therapies Inc ITCI -8%201%-21%-4%-72%205%-12%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Intercept Pharmaceuticals Inc ICPT -79%20%73%-46%-27%-4%128%99%0%0%0%0%0%0%0%0%0%0%0%0%0%
Intellipharmaceutics International Inc IPCI 0%0%-97%-72%41%-11%-39%48%-9%-4%83%0%0%0%0%0%0%0%0%0%0%
Insys Therapeutics Inc INSY 0%0%-64%5%-68%36%63%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Insmed Inc INSM 42%80%-58%136%-27%17%-9%154%119%-52%-18%64%-43%-6%-55%-10%-26%560%-88%10%0%
Innoviva Inc INVA -14%-19%23%33%0%0%0%0%-78%-70%12%0%0%0%0%0%0%0%0%0%0%
Innovate Biopharmaceuticals Inc INNT 0%-77%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Infinity Pharmaceuticals Inc INFI 120%-16%-42%50%-83%-54%22%-61%296%49%-4%-23%-16%-23%17%-44%-23%121%-62%-39%0%
IMV Inc IMV 13%-47%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Immutep Limited IMMP 58%-2%17%0%0%0%0%0%0%-83%50%0%0%0%0%0%0%0%0%0%0%
Immuron Limited IMRNW 140%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Immuron Limited IMRN 81%-37%10%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ImmunoGen Inc IMGN 30%7%-25%214%-85%122%-58%15%10%25%18%83%3%-18%-1%-42%75%63%-81%-23%290%
Horizon Pharma plc HZNP 95%84%34%-10%-25%68%69%227%-42%0%0%0%0%0%0%0%0%0%0%0%0%
Heron Therapeutics Inc HRTX -12%-8%43%38%-51%165%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Heat Biologics Inc HTBX 1035%-53%-74%-55%-65%-47%-35%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
GW Pharmaceuticals Plc GWPH 14%3%-26%18%61%3%63%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
GTx Inc GTXI 0%0%-94%141%-25%-4%-56%-61%25%27%-37%-75%17%-20%136%-44%0%0%0%0%0%
Grifols S A GRFS -21%27%-18%45%1%-2%-4%41%135%0%0%0%0%0%0%0%0%0%0%0%0%
Geron Corporation GERN 16%34%-44%-13%-57%49%-31%236%-5%-71%-6%19%-18%-35%2%8%-20%177%-59%-44%22%
Galectin Therapeutics Inc GALT -21%-18%3%241%-40%-53%-57%294%-64%0%0%0%0%0%0%0%0%0%0%0%0%
Fortress Biotech Inc FBIOP -6%43%-29%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Fortress Biotech Inc FBIO 28%176%-78%48%-3%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Five Prime Therapeutics Inc FPRX 343%-52%-58%-56%21%54%61%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Fibrocell Science Inc FCSC 0%0%-53%-66%-86%76%-36%8%-63%-22%-56%0%0%0%0%0%0%0%0%0%0%
Eyegate Pharmaceuticals Inc EYEGW 0%33%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Evoke Pharma Inc EVOK 61%-35%10%12%-39%-44%-21%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Evofem Biosciences Inc EVFM -61%56%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ESSA Pharma Inc EPIX 116%159%-52%-90%-48%0%0%0%0%-57%-73%-99%-74%-43%71%-77%10%125%-49%71%-16%
Esperion Therapeutics Inc ESPR -54%29%-30%426%-44%-45%194%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Epizyme Inc EPZM -47%260%-51%4%-24%-15%-9%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Enochian Biosciences Inc ENOB -35%-33%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Endo International plc ENDP 49%-40%-6%-53%-73%-15%7%157%-24%-3%74%-21%-3%-3%-9%44%9%151%-34%95%0%
Enanta Pharmaceuticals Inc ENTA -32%-13%21%75%1%-35%86%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Dynavax Technologies Corporation DVAX -12%-41%-51%373%-84%43%-14%-31%-14%4%125%69%-84%-44%118%-47%0%0%0%0%0%
DURECT Corporation DRRX -37%589%-48%-31%-39%180%-54%88%-22%-66%40%-27%-47%45%-12%55%31%24%-83%-3%0%
Diffusion Pharmaceuticals Inc DFFN 94%-80%-89%-48%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
DiaMedica Therapeutics Inc DMAC 93%66%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
DelMar Pharmaceuticals Inc DMPI 100%88%-69%-66%-15%16%-14%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Dare Bioscience Inc DARE 52%17%-67%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cytokinetics Incorporated CYTK 99%62%-22%-33%16%31%23%64%-31%-54%-28%2%-40%-37%14%-36%0%0%0%0%0%
CymaBay Therapeutics Inc CBAY 192%-75%-14%432%2%-83%0%0%0%0%0%0%0%-100%-94%0%0%0%0%0%0%
Cyclacel Pharmaceuticals Inc CYCCP 37%0%0%0%0%-31%-28%98%76%0%0%69%-61%-2%57%0%0%0%0%0%0%
Cyclacel Pharmaceuticals Inc CYCC 1200%3%-65%-67%-12%-29%-83%-34%47%-60%41%148%-92%-20%0%0%0%0%0%0%0%
Cumberland Pharmaceuticals Inc CPIX -38%-17%-18%34%5%-12%17%22%-22%-10%-56%0%0%0%0%0%0%0%0%0%0%
CTI BioPharma Corp CTIC 99%122%-73%-34%-67%-48%24%47%-78%-47%-68%714%740%-76%-19%-73%-7%20%-70%-46%543%
Correvio Pharma Corp CORV 0%-82%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%139%-78%-86%0%
Corcept Therapeutics Incorporated CORT 114%-9%-26%149%46%66%-7%124%-58%-11%39%173%-67%151%-66%-42%0%0%0%0%0%
Corbus Pharmaceuticals Holdings Inc CRBP -76%-8%-18%-16%412%-45%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ContraVir Pharmaceuticals Inc CTRV 0%0%-90%-70%-22%-31%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ContraFect Corporation CFRX 726%-60%51%-42%-63%36%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Conatus Pharmaceuticals Inc CNAT 0%-79%-63%-12%83%-59%9%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
CohBar Inc CWBR -12%-51%-37%142%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cocrystal Pharma Inc COCP 211%-87%-40%-48%-57%112%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Clovis Oncology Inc CLVS -59%-40%-74%53%27%-38%-7%277%14%0%0%0%0%0%0%0%0%0%0%0%0%
Citius Pharmaceuticals Inc CTXRW 63%300%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Citius Pharmaceuticals Inc CTXR 4%-1%-73%-43%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Chimerix Inc CMRX 139%-22%-44%1%-49%-78%166%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ChemoCentryx Inc CCXI 67%237%83%-20%-9%19%18%-47%0%0%0%0%0%0%0%0%0%0%0%0%0%
Chembio Diagnostics Inc CEMI 4%-20%-31%21%28%36%16%-29%41%-1%52%155%-59%-67%137%-51%0%0%0%0%0%
Checkpoint Therapeutics Inc CKPT 62%-13%-53%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cerecor Inc CERC -43%49%1%264%-74%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Celsion Corporation CLSN -55%16%-47%-37%-84%-18%-40%-89%382%-17%-37%49%0%0%0%0%0%0%0%0%0%
Cellectar Biosciences Inc CLRBZ 140%0%-90%19%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cellectar Biosciences Inc CLRBW 0%0%0%0%-68%-30%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cellectar Biosciences Inc CLRB -4%45%-89%12%-83%-76%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Celgene Corporation CELG 0%0%-39%-10%-3%7%32%115%16%14%6%1%20%-20%78%144%18%109%-33%-2%39%
Catalyst Pharmaceuticals Inc CPRX -7%92%-51%272%-57%-18%52%343%-66%30%57%-65%-48%-29%0%0%0%0%0%0%0%
Catalyst Biosciences Inc CBIO -11%-15%-42%40%-79%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Capricor Therapeutics Inc CAPR 185%223%-74%-41%-13%-18%15%0%0%0%0%0%0%0%0%0%25%50%33%-65%89%
Bison Capital Acquisition Corp BCACU 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Bison Capital Acquisition Corp BCACR 0%0%-26%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Bison Capital Acquisition Corp BCAC 0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
BioSpecifics Technologies Corp BSTC 0%-7%40%-22%30%11%78%45%-10%-35%-13%37%114%163%363%-45%0%0%0%0%0%
Bio Path Holdings Inc BPTH -54%4212%-91%-85%8%-53%-34%1043%0%-1%-18%-22%0%0%0%0%0%0%0%0%0%
BioMarin Pharmaceutical Inc BMRN 1%-1%-5%8%-21%16%29%43%43%28%43%6%-50%116%52%69%-18%10%-48%39%-18%
BioLineRx Ltd BLRX 8%423%-60%18%-29%-20%-42%11%-20%0%0%0%0%0%0%0%0%0%0%0%0%
BioDelivery Sciences International Inc BDSI -36%74%25%69%-63%-60%104%37%432%-77%-10%36%-1%-8%29%-30%30%43%0%0%0%
Benitec Biopharma Limited BNTCW 0%0%0%300%-95%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aytu BioScience Inc AYTU 505%25%-98%-91%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Avid Bioservices Inc CDMOP 1%7%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Avid Bioservices Inc CDMO 40%93%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AVEO Pharmaceuticals Inc AVEO 762%-60%-43%417%-57%50%-54%-77%-53%18%0%0%0%0%0%0%0%0%0%0%0%
Avadel Pharmaceuticals plc AVDL -11%175%-69%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aurinia Pharmaceuticals Inc AUPH -33%206%51%116%-15%-32%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Atossa Genetics Inc ATOS -47%60%-68%-81%-71%-78%-38%-41%0%0%0%0%0%0%0%0%0%0%0%0%0%
Athersys Inc ATHX 47%-14%-20%18%49%-35%-37%136%-39%-30%-40%818%-91%0%0%0%0%0%0%0%0%
Assertio Therapeutics Inc ASRT -73%-63%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Assembly Biosciences Inc ASMB -72%-8%-50%272%62%-4%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Arrowhead Pharmaceuticals Inc ARWR 21%417%238%137%-75%-17%-32%407%-49%-53%69%-42%-76%-14%3%-2%21500%100%0%0%0%
Array BioPharma Inc ARRY 0%0%11%46%108%-11%-6%35%72%-28%6%-31%-52%-35%84%-26%67%3%-63%66%0%
ArQule Inc ARQL 0%622%68%31%-42%78%-43%-23%-51%-4%59%-13%-27%-2%-3%6%19%60%-82%-47%212%
Arena Pharmaceuticals Inc ARNA 67%18%15%139%-25%-45%-41%-35%382%9%-52%-15%-47%-39%-9%112%8%-5%-46%-22%0%
Arbutus Biopharma Corporation ABUS 37%-32%-24%106%-45%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aratana Therapeutics Inc PETX 0%0%17%-27%29%-69%-7%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aptevo Therapeutics Inc APVO 5170%-51%-70%74%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Apricus Biosciences Inc APRI 0%0%-90%42%-87%-1%-62%33%-61%49%0%0%0%0%0%0%0%0%0%0%0%
Apellis Pharmaceuticals Inc APLS 89%120%-39%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ANI Pharmaceuticals Inc ANIP -53%36%-30%6%34%-20%181%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Amicus Therapeutics Inc FOLD 137%-0%-33%190%-49%17%254%-12%-22%-27%18%-50%-26%0%0%0%0%0%0%0%0%
Amarin Corporation plc AMRN -77%56%239%30%63%93%-50%-76%8%-9%473%101%-73%-89%90%-56%76%-61%-77%216%16%
AMAG Pharmaceuticals Inc AMAG 0%-19%15%-62%15%-29%76%65%-22%4%-52%6%-40%1%0%0%0%0%0%0%0%
Alzheon Inc ALZH 0%0%0%0%0%0%-70%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Altimmune Inc ALT 511%-13%-97%0%0%0%0%0%93%-97%-9%0%0%0%0%0%0%0%0%0%0%
Alpine Immune Sciences Inc ALPN 242%4%-67%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Alnylam Pharmaceuticals Inc ALNY 14%58%-43%239%-60%-3%51%252%124%-17%-44%-29%-15%36%60%79%0%0%0%0%0%
Alkermes plc ALKS 3%-31%-46%-2%-30%36%44%120%7%41%30%-12%-32%17%-30%36%4%115%-76%-16%28%
Alimera Sciences Inc ALIM -40%893%-46%23%-55%-56%18%199%26%-88%0%0%0%0%0%0%0%0%0%0%0%
Alexion Pharmaceuticals Inc ALXN 45%11%-19%-2%-36%3%39%42%31%78%65%35%-4%86%100%-20%48%20%-42%-62%116%
Albireo Pharma Inc ALBO 48%2%-4%44%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Akorn Inc AKRX 0%-60%-89%48%-41%3%47%84%20%83%239%-22%-69%17%37%19%0%0%0%0%0%
Akari Therapeutics Plc AKTX 4%10%-64%-38%-51%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Agios Pharmaceuticals Inc AGIO -7%5%-19%37%-36%-42%368%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AEterna Zentaris Inc AEZS -54%-70%25%-34%-20%-93%-57%-42%-74%-10%112%65%-68%46100%-33%0%0%0%0%0%0%
Aerpio Pharmaceuticals Inc ARPO 67%-66%-64%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Advaxis Inc ADXS -58%332%-93%-60%-29%26%89%13%-81%0%0%0%0%0%0%0%0%0%0%0%0%
Adamis Pharmaceuticals Corporation ADMP -32%-68%-49%40%-42%-12%-3%-47%318%-21%-33%0%0%0%0%0%0%0%0%0%0%
Achillion Pharmaceuticals Inc ACHN 0%282%-45%-30%-62%-12%269%-59%5%84%33%357%-86%-38%0%0%0%0%0%0%0%
Acer Therapeutics Inc ACER -35%-81%45%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AcelRx Pharmaceuticals Inc ACRX -46%-5%14%-22%-32%-43%-40%165%122%0%0%0%0%0%0%0%0%0%0%0%0%
Acasti Pharma Inc ACST -88%195%-12%-25%-51%-49%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ACADIA Pharmaceuticals Inc ACAD 24%167%-46%4%-19%12%27%437%331%-10%-9%47%-92%26%-11%45%0%0%0%0%0%
Abeona Therapeutics Inc ABEOW 0%0%-73%249%177%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Abeona Therapeutics Inc ABEO -52%-54%-55%227%44%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cue Biopharma, Inc. CUE -24%240%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Menlo Therapeutics Inc. MNLO -67%16%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Eyenovia, Inc. EYEN 45%36%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
resTORbio, Inc. TORC 0%-85%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sol-Gel Technologies Ltd. SLGL -43%186%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Evolus, Inc. EOLS -71%-2%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Biofrontera AG BFRA -31%-12%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
BioXcel Therapeutics, Inc. BTAI 367%162%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Arcus Biosciences, Inc. RCUS 175%-5%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Homology Medicines, Inc. FIXX -46%-5%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Unum Therapeutics Inc. UMRX 1528%-84%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Genprex, Inc. GNPX 1526%-75%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
MorphoSys AG MOR -22%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Unity Biotechnology, Inc. UBX -31%-54%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ASLAN Pharmaceuticals Limited ASLN -12%-43%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Evelo Biosciences, Inc. EVLO 165%-67%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kiniksa Pharmaceuticals, Ltd. KNSA 54%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Iterum Therapeutics plc ITRM -77%-17%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Verrica Pharmaceuticals Inc. VRCA -25%92%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Eidos Therapeutics, Inc. EIDX 120%330%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Xeris Pharmaceuticals, Inc. XERS -27%-57%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aptinyx Inc. APTX 3%-80%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kezar Life Sciences, Inc. KZR 38%-84%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Magenta Therapeutics, Inc. MGTA -47%163%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Forty Seven, Inc. FTSV 0%182%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Tricida, Inc. TCDA -81%61%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Crinetics Pharmaceuticals, Inc. CRNX -45%-20%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Allakos Inc. ALLK 49%83%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Constellation Pharmaceuticals, Inc. CNST -34%1066%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Provention Bio, Inc. PRVB 23%695%0%0%0%0%0%0%0%0%0%0%0%0%57%229%133%-40%-94%0%0%
Aquestive Therapeutics, Inc. AQST 3%-14%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Adial Pharmaceuticals, Inc ADIL -31%-53%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Vaccinex, Inc. VCNX -59%37%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aridis Pharmaceuticals Inc. ARDS 40%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Principia Biopharma Inc. PRNB 0%111%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Elanco Animal Health Incorporated ELAN 3%-7%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Y-mAbs Therapeutics, Inc. YMAB 64%52%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Entasis Therapeutics Holdings Inc. ETTX -53%23%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Arvinas, Inc. ARVN 98%217%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Urovant Sciences Ltd. UROV 21%101%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Equillium, Inc. EQ 39%-46%0%0%0%0%0%0%0%0%0%0%-22%-2%0%0%0%0%0%0%0%
PhaseBio Pharmaceuticals, Inc. PHAS -46%97%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Osmotica Pharmaceuticals plc OSMT -24%-10%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Eton Pharmaceutcials, Inc. ETON 12%17%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ObsEva SA OBSV -47%-71%30%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AnaptysBio, Inc. ANAB 38%-75%-37%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
BeyondSpring, Inc. BYSI -28%-16%-36%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Tocagen Inc. TOCA 0%-94%-20%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zymeworks Inc. ZYME 4%209%93%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
UroGen Pharma Ltd. URGN -49%-20%16%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Biohaven Pharmaceutical Holding Company Ltd. BHVN 62%44%37%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ovid Therapeutics Inc. OVID -49%85%-75%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
G1 Therapeutics, Inc. GTHX -32%40%-3%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Athenex, Inc. ATNX -29%24%-20%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Avenue Therapeutics, Inc. ATXI -36%65%49%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Mersana Therapeutics, Inc. MRSN 373%40%-75%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Dova Pharmaceuticals, Inc. DOVA 0%0%-74%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aileron Therapeutics, Inc. ALRN 70%-29%-92%0%0%0%0%-78%-75%-25%0%0%0%0%0%0%0%0%0%0%0%
Akcea Therapeutics, Inc. AKCA 0%-42%74%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kala Pharmaceuticals, Inc. KALA 84%-25%-74%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sienna Biopharmaceuticals, Inc. SNNA 0%0%-87%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zai Lab Limited ZLAB 217%74%9%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
NuCana plc NCNA -27%-57%43%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Deciphera Pharmaceuticals, Inc. DCPH -11%197%-7%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Rhythm Pharmaceuticals, Inc. RYTM 30%-14%-8%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
OptiNose, Inc. OPTN -57%57%-67%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Spero Therapeutics, Inc. SPRO 103%64%-48%0%0%0%-34%75%-19%-20%0%0%0%0%0%0%0%0%0%0%0%
scPharmaceuticals Inc. SCPH 7%38%-69%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Odonate Therapeutics, Inc. ODT -42%112%-44%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
BeiGene, Ltd. BGNE 52%19%44%222%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Proteostasis Therapeutics, Inc. PTI 0%-30%-44%-52%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Syndax Pharmaceuticals, Inc. SNDX 169%95%-49%22%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Hutchison China MediTech Limited HCM 13%13%-41%190%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Corvus Pharmaceuticals, Inc. CRVS -19%27%-65%-28%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aeglea BioTherapeutics, Inc. AGLE 1%6%38%24%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Spring Bank Pharmaceuticals, Inc. SBPH 0%-88%-23%68%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Merus N.V. MRUS 16%8%-28%-8%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Reata Pharmaceuticals, Inc. RETA -38%266%98%30%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Moleculin Biotech, Inc. MBRX -14%-6%-44%-18%0%0%0%0%0%0%0%19%-89%-60%-6%10%0%0%0%0%0%
Clearside Biomedical, Inc. CLSD -34%195%-85%-22%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Selecta Biosciences, Inc. SELB 37%-16%-73%-43%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Syros Pharmaceuticals, Inc. SYRS 63%24%-43%-20%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kadmon Holdings, Inc. KDMN -14%128%-43%-32%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Gemphire Therapeutics Inc. GEMP 0%-62%-90%1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Protagonist Therapeutics, Inc. PTGX 199%6%-68%-5%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Novan, Inc. NOVN -78%286%-80%-84%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AC Immune SA ACIU -37%-13%-26%-1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
AzurRx BioPharma, Inc. AZRX -29%-9%-67%-23%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ra Pharmaceuticals, Inc. RARX 0%157%114%-44%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Myovant Sciences Ltd. MYOV 77%-7%30%2%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Motif Bio plc MTFB 0%0%-39%75%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zosano Pharma Corporation ZSAN -60%-35%-80%-33%-66%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ascendis Pharma A/S ASND 26%111%56%98%10%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Flex Pharma, Inc. FLKS 0%0%-91%-34%-58%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Bellerophon Therapeutics, Inc. BLPH 1915%-57%-69%396%-82%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Eyegate Pharmaceuticals, Inc. EYEG -52%2014%-56%-34%-41%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Summit Therapeutics plc SMMT 254%26%-90%29%-26%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aduro Biotech, Inc. ADRO 0%-55%-65%-34%-59%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
XBiotech Inc. XBIT -18%277%29%-61%-7%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
KemPharm, Inc. KMPH 2539%-74%-56%37%-85%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Viking Therapeutics, Inc. VKTX -31%6%88%241%-65%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Blueprint Medicines Corporation BPMC 44%50%-29%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Collegium Pharmaceutical, Inc. COLL -4%20%-7%19%-43%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Jaguar Health, Inc. JAGX 9%187%-89%-80%-68%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Galapagos NV GLPG -52%128%-2%46%2%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Celyad SA CYAD -25%-43%-58%143%-67%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ritter Pharmaceuticals, Inc. RTTR 0%-73%-82%-88%59%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Catabasis Pharmaceuticals, Inc. CATB -64%34%-71%-59%-54%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Seres Therapeutics, Inc. MCRB 528%-15%-55%2%-72%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Chiasma, Inc. CHMA -16%63%83%-13%-90%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Neos Therapeutics, Inc. NEOS -59%-7%-84%74%-59%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
vTv Therapeutics Inc. VTVT 6%-32%-56%24%-29%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Intec Pharma Ltd. NTEC 648%-94%46%-10%6%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zynerba Pharmaceuticals, Inc. ZYNE -43%89%-76%-20%55%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aimmune Therapeutics, Inc. AIMT 0%39%-37%85%11%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Global Blood Therapeutics, Inc. GBT -43%89%4%172%-55%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Benitec Biopharma Limited BNTC -37%213%-49%93%-62%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Nabriva Therapeutics plc NBRV 86%-11%-76%0%-38%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aclaris Therapeutics, Inc. ACRS 261%-75%-70%-9%1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
CytomX Therapeutics, Inc. CTMX -16%-45%-28%92%-47%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Strongbridge Biopharma plc SBBP 19%-53%-38%202%-68%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Oasmia Pharmaceutical AB OASM 0%0%243%-68%-22%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
MyoKardia, Inc. MYOK 0%49%16%225%-12%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kura Oncology, Inc. KURA 134%1%-8%159%-30%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
WAVE Life Sciences Ltd. WVE -1%-81%20%34%64%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Axsome Therapeutics, Inc. AXSM -22%3630%-50%-17%-27%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Kitov Pharma Ltd. KTOV 0%14%-71%-27%-1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Retrophin, Inc. RTRX 91%-37%7%11%-2%58%75%109%0%0%0%0%0%0%0%0%0%0%0%0%0%
GlycoMimetics, Inc. GLYC -33%-41%-44%175%7%-21%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Dicerna Pharmaceuticals, Inc. DRNA 1%105%18%214%-76%-28%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Trevena, Inc. TRVN 172%86%-73%-73%-44%76%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ultragenyx Pharmaceutical Inc. RARE 243%-1%-6%-34%-37%156%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Cara Therapeutics, Inc. CARA -8%27%6%32%-45%69%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
uniQure N.V. QURE -49%149%47%250%-66%12%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Revance Therapeutics, Inc. RVNC 74%-19%-44%73%-39%102%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Eagle Pharmaceuticals, Inc. EGRX -23%49%-25%-33%-11%472%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Flexion Therapeutics, Inc. FLXN -43%78%-55%32%-1%-5%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Concert Pharmaceuticals, Inc. CNCE 36%-29%-51%151%-46%42%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Recro Pharma, Inc. REPH -84%157%-23%15%-10%215%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aquinox Pharmaceuticals, Inc. AQXP 0%0%-82%-29%32%66%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Achaogen, Inc. AKAO 0%0%-89%-18%127%-56%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Galmed Pharmaceuticals Ltd. GLMD -43%-15%-25%161%-54%31%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Akebia Therapeutics, Inc. AKBA -55%19%-63%43%-19%11%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aravive, Inc. ARAV -58%301%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Adamas Pharmaceuticals, Inc. ADMS 11%-56%-75%101%-40%63%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Phibro Animal Health Corporation PAHC -23%-23%-3%16%-1%-3%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Vital Therapies, Inc. VTL 0%0%-97%37%-62%-54%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Aldeyra Therapeutics, Inc. ALDX 10%-25%22%27%-21%-6%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
SCYNEXIS, Inc. SCYX 760%78%-79%-27%-49%-38%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Alder BioPharmaceuticals, Inc. ALDR 0%0%-10%-45%-37%14%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Agile Therapeutics, Inc. AGRX 21%312%-78%-53%-42%59%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Radius Health, Inc. RDUS -11%24%-48%-16%-38%58%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Zafgen, Inc. ZFGN 0%-78%7%45%-49%-80%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ardelyx, Inc. ARDX -11%312%-73%-54%-22%-4%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Amphastar Pharmaceuticals, Inc. AMPH 4%-4%3%4%29%23%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Minerva Neurosciences, Inc NERV -66%-2%11%-49%94%1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Sage Therapeutics, Inc. SAGE 22%-25%-42%223%-12%59%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Pfenex Inc. PFNX 0%263%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Ocular Therapeutix, Inc. OCUL 400%0%-11%-47%-11%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Bioblast Pharma Ltd. ORPN 0%0%-66%-56%-73%-39%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Marinus Pharmaceuticals, Inc. MRNS 433%-21%-65%708%-87%-28%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Catalent, Inc. CTLT 81%82%-24%52%8%-10%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Auris Medical Holding AG EARS 61%270%-22%-45%-78%25%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Otonomy, Inc. OTIC 82%77%-67%-65%-43%-17%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Affimed N.V. AFMD 118%-13%139%-28%-75%15%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
ProQR Therapeutics N.V. PRQR -56%-40%389%-34%-44%-60%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Vascular Biogenics Ltd. VBLT 67%17%-86%46%-8%-11%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Calithera Biosciences, Inc. CALA -13%43%-52%157%-58%-62%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Dermira, Inc. DERM 0%102%-74%-8%-12%91%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Forward Pharma A/S FWP -1%809%-79%35%-21%-9%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Xenon Pharmaceuticals Inc. XENE 9%110%123%-63%-4%-59%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
FibroGen, Inc FGEN -13%-6%-2%121%-30%11%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%
Bellicum Pharmaceuticals, Inc. BLCM 189%-60%-65%-38%-33%-12%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%